Nothing really was known about the chemistry of that layer, but when I'd done some preliminary work on it, using histochemistry, it gave reactions which were markedly different from those of keratin. When cysteine is absorbed down the lower gut, it goes into the blood and around the body to the follicles. [laugh]. But it's a matter of the efficacy of the methodology one develops, and of economic applicability. ... Grace English is a Senior Analyst at SRG Partners and has over 2 years’ experience in providing CFO services in Adelaide. The use of information provided here for any other purpose, including In 2002, when I spoke to him, he had been appointed as Executive Dean of the Faculty of Sciences. But analytical techniques then were not what they are today, so it was a quantitative business, and I had to get enough material. George, which college did you go to in Cambridge? Since then he has made outstanding contributions in the areas of wool and hair follicle development, wool fibre production and sheep transgenesis. electronic format, is strictly prohibited. But that was in the early 1970s, when there was much discussion about the dangers of 'molecular engineering'. I was very interested in what was going on molecularly in this – and we still don't know. One of the enduring memories I have of my early life is of some loneliness. Rivett was the first Executive of CSIR, which was set up by the Commonwealth government in 1926, and in 1928 he asked Robertson whether he would like to set up a division on sheep nutrition – he knew that, in addition to all the insulin work, Robertson had done a lot on animal growth and wool growth. The master for that was very nice, but he had served in France in the First World War and told us stories about his experiences rather than teaching us the language. If it has softness, in particular' – which this wool had – 'then we don't mind. As our animal we used guinea pigs: having a colony of them, we were able to use young guinea pigs, in which all the follicles are active. Our findings relate back to the point you were making about the establishment of the ortho-para condition that is in wool, in that the IF, the intermediate filaments, are turned on very early, low down, and the disposition on one side can be seen. Yes. I remember that a very nice man, a Mr Still, worked behind the counter and displayed quite a reasonable knowledge of chemistry. Barry Powell, in particular, had taken this on. [laugh]. I think that all of this transgenic work in engineering animals, particularly sheep, will happen eventually if it can be shown to be economically of advantage to the producer, if desirable changes to wool or to the metabolism of the sheep can be made. Legge gave me a research topic outside his prime interest, which was in bacterial and animal cell metabolism, saying, 'Why don't you have a go at purifying this polypeptide hormone?' We had found that the proliferation of cells in the follicle and the continuous proliferation to make a keratinous structure is dependent upon the vitality of the dermal papilla – which is a dermal component inside the bulb (an epidermal structure) of the hair follicle and is itself a modification of the general dermis: a collagenous fibroblastic tissue that is in skin, be it avian (chicken) or mammalian (sheep or human). In order to do that, I realised, after removing the follicle by plucking it out of the skin one could actually micro-dissect off the sheath – it would come away quite easily – under a dissecting microscope. I am quite sure that he would have been a leader in Australian science, had his life not been shortened. I will discuss that a little later. (She lived on her own while my father was away carrying out his duties.) So that really wasn't an option, and we had to look for overexpression. I was retired and I really didn't like facing up to such a move, with travel every day, nor did two of the people who were with me. Phosphorylation is the major modification in post-translational changes in proteins, but citrullination is also one, and has been shown to occur with transcription factors in the nucleus. That work was published in a conference. There seemed to be a jinx on the building. People left, grants were curtailed and so forth. I enjoyed lecturing to students – which was rather different, when I first moved, from what I had been used to in CSIRO. That was how I came to collaborate with you, Bruce, in those early days, on wool and hair structure. In fact, it ended up being delivered on the day Sputnik went up, a day I can readily remember. This was a bolus of money that made an enormous difference, because you could anticipate doing things that you couldn't do with normal funding. I used to have a few hours off during the week to go to early classes, but mostly it was full on, and it was all very hard work. Robertson was a brilliant biochemist and was the first to manufacture insulin outside of Canada. Yes, and I was awarded a scholarship to take an MSc degree as a precursor to a PhD, because there wasn't an honours course at that time. I took a lot of pains to make sure the identification was correct, and it turned out to be the amino acid citrulline, which is related to arginine. They have now been studied in considerable detail. I don't think I was any more than in the middle range as a lecturer, although in my day there was no compulsory feedback from students. Born in Broken Hill, New South Wales, Australia on 8 Apr 1907 to George Rogers and Grace Beatrice Allen. Directory are not limited to University employees. The information in this directory is provided to support the academic, When I was about a year old, the family moved to a new house in Caulfield, in Melbourne, where I grew up and lived until I left home. The staff were a marvellous support and did a lot of the hard yakka, so it wasn't too bad, but it meant that there were a lot more committee meetings and such things to take one away from the lab. He had grants for work related to cancer and he wondered whether I'd be interested in applying for a job as a biological electron microscopist (which I suppose I was for that period). You then realised, I think, that you could benefit from gaining a PhD. Only a small percentage of school leavers attended university, and it was a privilege to be there. I said I would like to continue doing some research, he made it possible for me to have a lab in the new Molecular Biosciences Building and to share an office. The idea was: could one devise a biochemistry in the rumen that would grab that sulphur and bring it back into metabolic use? We still don't fully understand the physics of curliness, but the bilateral structure is sure to have some function. Download Low Res Image. So, where did it come from? Get Full Access To George's Info Yes, indeed. They had an RCA electron microscope that the late Lloyd Rees FAA had arranged to have shipped out from the USA to Melbourne just after the war. As to research, I had the advantage of full-time research in those early years in CSIRO, which included collaboration with you, and that was a good experience. Well, I graduated with first-class honours with my MSc in 1951. Timothy Allen received the inaugural Emeritus Professor George Rogers … George Rogers in California . Well, we were able to use the money to really expedite my research and that of all the other members of our 'gang of four'. Much as I was interested in structure, I was very much interested in the biochemistry of the formation of these keratinous tissues. 162422014, citing West Terrace Cemetery, Adelaide, Adelaide City, South Australia, Australia ; … She has graduated in a diploma course at the university in higher education and has won several prizes for her work. I was appointed a research officer, and renewed an association with wool, keratins and so on that has remained with me for the rest of my life. It was done by the old method of paper chromatography, and, lo and behold, there was a pattern of spots of amino acids distributed on this two­dimensional chromatogram that were different in intensity from what you see if you hydrolyse keratin and separate its amino acids. And you and I used a very nice light microscope, a Leitz microscope, which was the best microscope we had around the place before our electron microscope came along. He did, yes. I've always enjoyed fishing – but in the sea, not in rivers. Also, we turned over to a semester system, which meant reorganising the system of teaching. In any case, the University of Adelaide decided to open up the Roseworthy campus, which was actually near Turretfield where we'd been working with the biologists, some 60 kilometres out of Adelaide. But I flew around and went across to the West Coast, visiting some major labs. There are several tens of different genes, maybe 50, but the encoding DNA sequences differ only slightly. Many of these secrets are now being revealed. He was a visiting fellow at Clare Hall in Cambridge in 1970, a visiting researcher at the University of Grenoble, France, in 1977 and a visiting scientist in 1985 at the National Institutes of Health, in Washington. I then found that having a chemistry set was an outlet in the lonely hours that I, like many other schoolchildren, spent quarantined at home during the poliomyelitis epidemic of 1937. Also, the projects from whoever participated had to be able to be interlinked. She is now a lecturer, although she doesn't have a PhD and has no postdoc or postgraduate students. I added to my chemistry laboratory over some years. George Rogers is a Director of SRG Partners and has over 15 years’ experience in the commercial sector. But a year later he asked me again and, I guess as a sort of carrot, the University had raised the appointment to a Readership. I was admitted as a matriculant, and my supervisor was Arthur Hughes, A F W Hughes, a distinguished embryologist and cell biologist. My parents were married in 1916, a year my mother remembered for the bombing raids on London by German Zeppelins. Because of the chemistry interest I had an ambition to be an industrial chemist. I did well in the subjects I took, except French. Knockout in mice is hard enough to do, but a knockout procedure in sheep was almost beyond belief. He joined the Department of Biochemistry at the University of Adelaide in 1963 where he began as a reader (1963–77), before being promoted to professor (1978–92). First, this work is very expensive; in addition, even genetic engineering in plants was having a difficult time being accepted but to have a genetically engineered sheep – harmless though that would be – was regarded as completely unacceptable to the public. I continued on in a honorary capacity and we still maintained our lab, but we had to move it to a site which was run by SARDI, and we became beholden to SARDI. They worked mainly on chick, but I and many others realised that this tied in with work already done on the mammalian system. Member Australian Society of Biochemistry and Molecular Biology (Lemberg medallist 1976). George Rogers. This ship took a route via Jakarta, but the Italians on the ship wouldn't let people go ashore until several of us, of about my age, told an officer that we really wanted to go. But that was only for a short time. Download Low Res Image. Not only that, but the wool became more lustrous as a result of that overexpression. George Ernest Rogers, Australian biochemist. I had help from other heads of department to sort out the administrative matters, and I was able to establish my own research group and get on with the work. View George Rogers’ profile on LinkedIn, the world’s largest professional community. Jakarta was interesting, and was very old world and underdeveloped compared with today. We had done some work on feather keratin as well as mammalian keratin, and you were bowling along at a great rate with the high­resolution cameras and all that sort of thing. I couldn't be bothered competing, though. But we were able to show that there are many genes encoding these families, and that was a major finding at that time. People Projects ... Adelaide, SA, Australia Immediate Family: A nice thing about my time in France was that I was able to work in the labs that your friend Andrew Miller was heading up at the EMBL [European Molecular Biology Laboratory] outstation in Grenoble. It was only approximate but, if I got an increased activity during purification, I could detect it. I corresponded with Gordon Lennox, the chief of the unit in Melbourne, and said, 'With so many things in this field going on in America, would it be possible to do a trip around, to visit the major labs and talk to the senior people in that area of biological electron microscopy?' That slowly became the central focus. It was a great occasion. That was by luck rather than planning, I think, but we gained a lot from that kind of established group culture. I used the snout that has large whisker, vibrissae, follicles. When this happened in mice, and we got changes, I said to Barry that we'd better do the same with sheep, to see what would happen. The arginine could be converted at some level of protein synthesis, such as at the tRNA level, and then be incorporated. In 1992 So he put salt on the ice and reduced the temperature to minus 10, and the yield increased. And there was Hugh Ennor (later Sir Hugh), the foundation Professor of Biochemistry and Fellow of the Academy. He served in the First World War as a transport driver in the Royal Naval Air Service, which later became the RAF, and after the war was a motor car buyer for a prominent export company in the City of London. It has been refurbished a little bit, so it lights up with fluorescent tape.. [laugh]. and SARDI decided that we could. Sadly, quite a few of the older cadets were to lose their lives on active service. When I was around 11, I think, I jumped a year into a higher class because of when my birthday occurred, and I fell behind. I enjoyed the chemistry, though, because Hartung, the professor at that time, was another excellent lecturer. I used the partial reduction and then applied electron stains – osmium tetroxide, lead salts and so on – and revealed this structure in all its beauty. Then that strange spot was finally identified. George's parents emigrated to Australia from England in the 1920s and he was born in Melbourne in 1927. He agreed and, thankfully, he was able to dig up some money for me to do that. Select this result to view George M Rogers's phone number, address, and more. Because I wasn't far off retirement myself, I had a kind of watching brief rather than being able to do anything very positive. In 1963 you left CSIRO and moved to the University of Adelaide. Inaugural Emeritus Professor George Rogers AO Supplementary Scholarship Awarded. policy. Wasn't it in Cambridge that you came into contact with the very first scanning electron microscope? Yes. George Rogers First World War Embarkation Roll George Rogers. I still have photographs of two or three American colleagues in the field, and of Joe Rothnagel, who was a PhD student of mine and did a postdoc, and then went to the United States and stayed in Baylor [College of Medicine], in Houston, for nearly 10 years. My father, Percy, was born in London. There was a flavour injected by the influx of service men and women: before the war universities had been a bit of a playground, but it became quite a serious matter to take your education there. They did learn how to do it, but couldn't bring it back to us. So the animal suffers a loss of cysteine input. Her brother Richard was a chemist nearby in Ciba-Geigy, at Duxford, the makers of Araldite so we went to him and explained that we wanted some sort of embedding medium that was better than what was available. That was very interesting. But I left school earlier than originally intended, when I was still too young to excel in sport. When I got back to Adelaide from study leave, our main thread of funding was for wool research so the mammalian keratin work was the main focus. He has been an invited speaker at scientific meetings in Europe, the United Kingdom and the USA, and has published over 170 papers and reviews and two books. Audrey spent a lot of time working on TEM of bacteria in the Cosslett group. I recall one episode when I was sorely disappointed at failing a physics exam at the end of term. 696 Bourke Street. I suppose I'd start with teaching. And so, even though over the time we had about $2 million to do this work, we just couldn't get far enough. And in our various ways we slotted into doing that. It was pretty tough because there was no time to do much for relaxation, but I did play tennis on Saturday afternoons. Pioneering as that early work was, it was overwhelmed by subsequent work by German colleagues in Heidelberg, who did a superb job, an amazing amount of very fine work. It was all solved by the appointment of Bill Elliott in 1965 as the Professor and Head of the department, leading to 25 or 30 years of fantastic science. When you look back over your academic studies and your research at the bench, what do you consider to be the greatest contributions you've made? It is a gastrointestinal hormone. My younger daughter, in her early years, suffered from an illness, but she recovered from that and has done a BA at RMIT. I decided that it would be a good idea for us in the third year to build a model of lysozyme, which was the first enzyme to have its tertiary structure solved in this way. I had discussions, with Peter Rathjen, a graduate of our department and who had become the Professor of Biochemistry. *Address correspondence to: Dr. George Rogers. Even that came to an end, because SARDI wanted the two people with me to go out to Roseworthy campus, which they did despite commuting problems. I had thought about getting seal whiskers or something like that, but in the end I used rats. right to recover all costs incurred in the event of breach of this The really important thing was that I was seconded to the electron microscopy group at the Cavendish Lab. You had to move from the university, though, didn't you? School of Molecular and Biomedical Sciences, University of Adelaide, South Australia. At first I went to a kindergarten-primary school combination about half a kilometre from our home. In retrospect, I should have gone on to a public school; things might then have been different. Would you tell me something about your family? In the course of our studies we sequenced the genes for many of these. And the follicle is such a small structure that microscopy had to be an important part of it. I can't remember now whether there was a restriction, but we felt that we couldn't go beyond four because there would be just too much dilution of the funding. [email protected]. Because of the loss of staff, only four of us were left who could undertake the second- and third­year teaching, but we shared the load. I used to weigh the amount of material at each step, make it up to a volume, inject it and count the number of drops. He has been extremely successful in that and I'm glad it happened, but I wasn't so glad at the time, because I had to do a second stint as head. And this would occur later than the arginyl-tRNA possibility, would it? My parents had emigrated from England some four years earlier, together with their infant daughter, my only sibling. The wool fibre, like hair fibres generally, grows up out of a follicle, and it has a surround of another cellular layer called the inner root sheath. There would have been a lot of ex-servicemen coming home at that time. During his years with CSIRO he was awarded an overseas studentship and completed a PhD at Cambridge. 1916, Photograph, B 73677 Studio portrait of George Edwin Rogers in his army uniform, together with his parents and two of his brothers - Walter (left) and Harvey (centre). Arginine has a so-called guanidino side chain, which is basic, whereas citrulline has an ureido, urea-type side chain, which is not basic but neutral. I remember that we had to leave our home and move temporarily to a friend's house. We got a few pictures (I may even have sent them to you) but actually it was an interesting sidelight to what I was mainly doing. That was an exciting time: we were going to get our own Siemens electron microscope. We had funding from the South Australian Research and Development Institute (SARDI), a research branch of the agricultural department, as well. Bill Elliott, the head of the department took up the whole idea and encouraged it, becoming part of the subsequent arrangement. In the late 1950s it was not known how proteins were synthesised. So we set up a program, with the collaboration of SARDI because we already had links for other reasons with reproductive biologists at Turretfield research farm and a group there had been developing the transgenic technique. Biog Observer 18/6/1898 p1168a-b. In fact, their original intention was to stay in Australia for only five years, but the Depression and the subsequent World War II rather stopped all that. Melbourne. My father had been successful in the motor business in Melbourne and was, I believe, the first to establish second-hand car auctions. The top city of residence is San Diego, followed by Stockton. We had a stroke of luck, in that we were able to purify enough of the enzyme from guinea pig skin to do an N-terminal analysis, getting just enough sequence that we could make a nucleotide probe, probe DNA and isolate the gene. He said, 'Well, you go at your own risk' – because the Dutch and Europeans generally weren't very much liked in Indonesia at that time and were getting out. When I joined the same laboratory in 1952, George was working on the structure and biochemistry of the wool follicle, and over the next 10 years we collaborated on various aspects of the molecular structure and cellular structure of keratins such as wool, hair and feathers. By then the school mechanism had come in, in which Molecular Biosciences consisted of biochemistry and genetics, and physiology and microbiology, and so all these groups were becoming bigger. Several of us were interested. Find a Grave, database and images (https://www.findagrave.com: accessed ), memorial page for Harrold George Rogers (unknown–20 Jan 1958), Find a Grave Memorial no. I had no desire to follow my father into the business world, particularly his business; it always seemed to be full of balance sheets and sales, and it didn't really fascinate me as chemistry did. I found it very stimulating. Managing Director. There was a lot to be discovered, and I'll always remember that the mission when we were appointed was to find out everything one could about wool. The para- and the orthocortex had been discovered by Horio and Kondo some years before by staining with dyes and using a light microscope. I thought it was fabulous, because it enabled one to learn full time and to socialise, and it was really quite a change in my life pattern. I enrolled for that, and my supervisor through the course of my MSc was Jack Legge, a brilliant man with a very agile mind. In 1963 he left CSIRO to take up a readership in biochemistry at the University of Adelaide, where he continued his study on wool and other keratins. As interesting as that might have been, I don't think the frog embryo would have been the best model. It didn't really attract me to continue there and do much about it. By the way, we had been working with quills off porcupines and echidnas, and I think you took a very nice picture of one of those, too. I have always been fascinated by that step in which the final changes take place, the disulphide bonds link up in the 'region of fibre hardening'. George has performed a variety of roles including Strategic Planning Manager (ASX Mining Company), Investor Representative (ASX Investment Company), and Financial Analyst (ASX Energy and Gas Company). It was logical, then, to call it peptidylarginine deiminase (PAD) because the arginine had to be blocked at both the amino and carboxyl ends. People moved with me, and we were able to set up a big lab. Join Facebook to connect with George Rogers and others you may know. It appeared gradually, but suddenly became accessible and ultimately was initiated in our Department. That left an indelible impression on me and also led to a network that was beneficial in later years. Although we were unable to do very much in the human model, I was able to go to conferences on differentiation in keratinising systems and to keep up with what was going on in the human field regarding hair growth, which is now seen as an amazing system with all sorts of regulatory factors. As I talked to him I learned that he was developing the scanning microscope, the first one in the world, and I did a brief study with one of his students to look at hair and wool surfaces with this machine. That was a bit of a shock, when I had been there for only six months. She has surpassed me in teaching excellence. At Trinity I was part of a group of research students who had a mentor; that was C E W Oatley, who became Professor of [Electrical] Engineering. So there was a great unification of approach. Amos Roland Rogers 05 Jul 1884 Berry Mills, ... Richard Sanders Rogers bef 02 Dec 1861 Adelaide, Province of South Australia - 28 Mar 1942 managed by Leandra Ford. Actually, he was the second chief of a division in CSIR. That was for studies of the keratinisation process, which involved looking at mechanisms of protein synthesis that we were learning by studying other systems, and to enable us to examine the hardening process. In 1976 George was awarded a DSc by the University of Adelaide and also the Lemberg Medal of the Australian Biochemical Society. You continued your work in the Commonwealth centre, I think. At about that time, also, you went off to France for a break, didn't you? Gordon Lennox suggested you should change your study direction a bit, didn't he? It is a very tough industry but she is skilled, and enjoys it, which is good. However, he was encouraged by the director of his laboratory to aim for a degree rather than a diploma and, after two years of study, gained admission to Melbourne University to study for a bachelor's degree in chemistry and biochemistry. The counter-aspect was that the fibres were weakened, yet when we had a conference in which some textile manufacturers were present they said, 'Don't worry about that; we can handle that. The University of Adelaide Along the way with that work, we examined the expression of the genes of these keratin families during the growth phase. George E Rogers . [email protected] Received: 26 March 2019; Accepted: 9 April 2019; Published: 9 May 2019 Abstract: The cuticle is the outermost layer of overlapping flattened cells of hair and has been subjected to many years of study to understand its structure and how it develops in the follicle. Emeritus Professor George Rogers AO received a PhD (1963) and a Doctor of Science (1978) from the University of Adelaide. 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