95, 5672–5677. Lack of a significant effect of deletion of the tachykinin neurokinin-1 receptor on wound healing in mouse skin. Natl. Dermatol. 135, 227–239. Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L. & Fuchs, E. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Hansen, L. A., Alexander, N., Hogan, M. E., Sundberg, J. P., Dlugosz, A., Threadgill, D. W., Magnuson, T., and Yuspa, S. H. (1997) Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. 108, 695–700. Acad. (2000) Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice. Muro, A.F., Chauhan, A.K., Gajovic, S., Iaconcig, A., Porro, F., Stanta, G., Baralle, F.E. 9, 386–390. Am. View the profiles of professionals named "Sabine Werner" on LinkedIn. Raja, K., Sivamani, M. S., Garcia, R. R. & Isseroff, R. R. Wound re-epithelialization: modulating keratinocyte migration in wound healing. 374, 360–363. 50, 1131–1137. Gonzalez-Suarez, E., Samper, E., Ramirez, A., et al.. (2001). 122, 465–473 (1993). Massagué, J. J. Pathol. Lond. ‪University of Konstanz‬ - ‪Cited by 4,434‬ - ‪Management‬ - ‪especially strategy and leadership‬ - ‪organizational behavior‬ - ‪diversity‬ - ‪cultural industries‬ 112, 835–842. Invest. Cell Sci. VAT will be added later in the checkout.Tax calculation will be finalised during checkout. Invest. Derynck, R., Zhang, Y., and Feng, X. H. (1998) Smads: transcriptional activators of TGF-β responses. Invest. Michalik, L. et al. 35, 358–366. 132, 866–876. 20, 5361–5372. Wound healing in the PU.1 null mouse — tissue repair is not dependent on inflammatory cells. Beer, H. D., Florence, C., Dammeier, J., McGuire, L., Werner, S., and Duan, D. R. (1997) Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression. Natl Vital Stat. Gurtner, G. C., Callaghan, M. J. Add co-authors Co-authors. You are using a browser version with limited support for CSS. Low, Q.E., Drugea, I.A., Duffner, L.A., et al. & Barrandon, Y. Curr. Sci. Their combined citations are counted only for the first article. Dev. 134, 136–151 (2001). A. 127, 696–704. 230, 260–265. Science 266, 819–822 (1994). Yang, X., Castilla, L. H., Xu, X., Li, C., Gotay, J., Weinstein, M., Liu, P. P., and Deng, C. X. Braun, S., auf dem Keller, U., Steiling, H. & Werner, S. Fibroblast growth factors in epithelial repair and cytoprotection. Incisional wound healing in transforming growth factor-beta1 null mice. About this article. Google Scholar. Google Scholar Werner, K. J. , V. Nangia , J. O. Smith III , and J. S. Abel , " A General and Explicit Formulation for Wave Digital Filters with Multiple/Multiport Nonlinearities and Complicated Topologies ", IEEE Workshop on Applications of Signal Processing to Audio and Acoustics (WASPAA) , New Paltz, New York, October/2015. 4, e234 (2007). 117, 1382–1390. A., and Williams, L. T. (1991) Inhibition of PDGF b-receptor by co-expression of a truncated receptor. Surg. Dev. Front. Article  Cell (1997) Biological roles of fibroblast growth factor-2. Sci. Massague, J. and Wotton, D. (2000) Transcriptional control by the TGF-beta/Smad signaling system. 205, 379–386. Invest. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing. 95, 737–740. PubMed  J. Selman, M., King, T. E. & Pardo, A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Med. 6, 1147–1153. 11, 996–1007. Cole, J., Tsou, R., Wallace, K., Gibran, N. & Isik, F. Early gene expression profile of human skin to injury using high-density cDNA microarrays. Wnt and TGF-β expression in the sponge Amphimedon queenslandica and the origin of metazoan embryonic patterning. AD Werner, Q Zhang, L Xue, BD Smerdon, X Li, X Zhu, L Yu, L Li. The ones marked * may be different from the article in the profile. Mol. 93, 6594–6599. Surgery. Biochem. Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism. Med. Sehen Sie sich das Profil von Sabine Werner im größten Business-Netzwerk der Welt an. 14, 2525–2531. Proc. Ito, M. et al. 269, 234–238. ADS  Wound epithelialization deficits in the transforming growth factor-alpha knockout mouse. Mohan, R., Chintala, S.K., Jung, J.C., et al. TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. J. McGee, G. S., Davidson, J. M., Buckley, A., Sommer, A., Woodward, S. C., Aquino, A. M., Barbour, R., and Demetriou, A. B 359, 753–757 (2004). Sci. Wound Repair Regen. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. 163, 445–452. Wang, X. J., Liefer, K. M., Tsai, S., O’Malley, B. W., and Roop, D. R. (1999) Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis. USA Cell 102, 451–461 (2000). 4, 879–889. Merged citations. Location of stem cells of human hair follicles by clonal analysis. Science c-Jun is essential for organization of the epidermal leading edge. Yang, L., Chan, T., Demare, J., Iwashina, T., Ghahary, A., Scott, P.G., Tredget, E.E. Cytokine Growth Factor Rev. Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Zhao, M. et al. Curr. Reed, B. R. and Clark, R. A. Development. 108, 985–1002. B. c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. B., Huh, C.-G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. Dev Dyn. She earned her Ph.D. at the University of Munich, after having completed her dissertation at the Max-Planck-Institute of Biochemistry in Martinsried in the department of Prof. Peter Hans Hofschneider. Invest. Liechty, K. W., Kim, H. B., Adzick, N. S., and Crombleholme, T. M. (2000) Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair. Shah, M., Revis, D., Herrick, S., Baillie, R., Thorgeirson, S., Ferguson, M., and Roberts, A. Wound healing recapitulates morphogenesis in Drosophila embryos. Amendt, C., Mann, A., Schirmacher, P. & Blessing, M. Resistance of keratinocytes to TGFβ-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds. Sci. Motil. Sci. Acad. Flanders, K.C., Sullivan, C.D., Fujii, M., et al. Sabine Werner (born 5 September 1960 Tübingen) is a German biochemist and professor of cell biology at ETH Zurich. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Sabine Werner handcrafts one of a kind jewellery in sterling silver, resin, genuine sea glass and gemstones in her studio near Aix en Provence. Wood, W. et al. Toyoda, M., Takayama, H., Horiguchi, N., et al. (Ab 2./3. J. Invest. Nature 449, 1003–1007 (2007). Dermatol. This article focuses on the studies in which genetically modified mouse models have helped elucidate the roles that many soluble mediators play during wound repair, encompassing the fibroblast growth factor (FGF) and transforming growth factor-β (TGF-β) families and also data on cytokines and chemokines. Am J Pathol. Nature Cell Biol. Surg. Ashcroft, G. S., Lei, K., Jin, W., Longenecker, G., Kulkarni, A. 107, R9-R14. Biol. (2002). Tan, N.S., Michalik, L., Noy, N., et al. (2001). Disruption of protein kinase C eta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis. Ghahary, A., Shen, Y. J., Scott, P. G., Gong, Y. ‪Lecturer in Vegetation Management, University of New England‬ - ‪Cited by 1,098‬ - ‪plant ecology‬ - ‪ecosystem functions‬ - ‪forest‬ - ‪plant functional traits‬ - ‪plant-soil interaction‬ 286, 361–375 (2005). B., Weinstein, M., Letterio, J. L., Mizel, D. E., Anzano, M., Greenwell-Wild, T., Wahl, S. M., Deng, C., and Roberts, A. Streit, M., Velasco, P., Riccardi, L., Spencer, L., Brown, L.F., Janes, L., Lange-Asschenfeldt, B., Yano, K., Hawighorst, T., Iruela-Arispe, L., and Detmar, M. (2000) Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice. Learn more about Institutional subscriptions. c-Met is essential for wound healing in the skin. 223, 371–378. 159, 457–463. This is a preview of subscription content, access via your institution. Im Profil von Sabine Werner ist 1 Job angegeben. PLoS Biol. Correspondence should be addressed to G.C.G. J. A. Trends Pharmacol. Amendt, C., Mann, A., Schirmacher, P., Blessing, M. (2002). (2002). USA A role for skin γδ T cells in wound repair. Sci. Development 131, 3021–3034 (2004). Peterson, J. J., Rayburn, H. B., Lager, D. J., Raife, T. J., Kealey, G. P., Rosenberg, R. D., and Lentz, S. R.4.4 CXCR2 Null Mice Show Multiple Defects in Wound Healing. Opalenik, S. R. & Davidson, J. M. Fibroblast differentiation of bone marrow-derived cells during wound repair. Int. J. Pathol. Werner, S., Smola, H., Liao, X., Longaker, M. T., Krieg, T., Hofschneider, P. H., and Williams, L. T. (1994) The function of KGF in epithelial morphogenesis and wound re-epithelialisation. Sci. 28, 147–166 (2004). Sabine Werner नाम के लोगों की प्रोफ़ाइल देखें. A dermal niche for multipotent adult skin-derived precursor cells. Klapka, N. & Müller, H. W. Collagen matrix in spinal cord injury. FASEB J. Jameson, J., Ugarte, K., Chen, N., et al. Timo currently plays as a striker for Germany national team and Chelsea. Eckes, B., Colucci-Guyon, E., Smola, H., Nodder, S., Babinet, C., Krieg, T., and Martin, P. (2000) Impaired wound healing in embryonic and adult mice lacking vimentin. Sabine Werner has 15 books on Goodreads with 434 ratings. USA Their combined citations are counted only for the first article. A., and Fiddes, J. C. (1990) Basic fibroblast growth factor stimulation of epidermal wound healing in pigs. J. (2003). Paul Hiebert & Sabine Werner. Cell 124, 241–245 (2006). Braun, S., Hanselmann, C., Gassmann, M.G., et al. (1999) Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. Molecular Biotechnology Sci. Ferguson, M. W. & O'Kane, S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Huang, X., Griffiths, M., Wu, J., Farese, R. V. Jr., and Sheppard, D. (2000) Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice. Munz, B., Smola, H., Engelhardt, F., Bleuel, K., Brauchle, M., Lein, I., Evans, L. W., Huylebroeck, D., Balling, R., and Werner, S. (1999) Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. Guo, L., Degenstein, L., and Fuchs, E. (1996) Keratinocyte growth factor is required for hair development but not for wound healing. Adv. Carmeliet, P., Schoonjans, L., Kieckens, L., Ream, B., Degen, J., Bronson, R., De Vos, R., van den Oord, J. J., Collen, D., and Mulligan, R. C. (1994) Physiological consequences of loss of plasminogen activator gene function in mice. 20, 5248–5255. Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. Development Historically, animal models of repair have taught us much about how this repair process is orchestrated and, over recent years, the use of genetically modified mice has helped define the roles of many key molecules. Google Scholar. Levenson, S. M. et al. Plenum, New York, pp. Join Facebook to connect with Sabine Werner and others you may know. Cell 118, 635–648 (2004). (2003). Vasioukhin, V., Degenstein, L., Wise, B., and Fuchs, E. (1999) The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. FEBS Lett. 41, 24, 197–24,203. Lyons, K. M., Pelton, R. W., and Hogan, B. L. (1989) Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. & Brockes, J. P. Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate. 4, 865–877. Invest. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. Biol. Adv. (1985) Cutaneous tissue repair: practical implications of current knowledge. Proc. Proc. Hocevar, B. Honegger, A. M., Schmidt, A., Ullrich, A., and Schlessinger, J. Cell Biol. PubMed  Am. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. 13, 1122–1128 (2003). She is an editor of European Journal of Cell Biology. Inflammatory cells during wound repair: the good, the bad and the ugly. 11, 1873–1884. Exogenous transforming growth factor-β amplifies its own expression and induces scar formation in a model of human fetal skin repair. Abbott, R. E., Corral, C. J., MacIvor, D. M., Lin, X., Ley, T. J., and Mustoe, T. A. By submitting a comment you agree to abide by our Terms and Community Guidelines. Med. Aarabi, S., Longaker, M. T. & Gurtner, G. C. Hypertrophic scar formation following burns and trauma: new approaches to treatment. Frye, M., Gardner, C., Li, E.R., Arnold, I., Watt, F.M. Annu. Kyriakides, T. R., Tam, J. W., and Bornstein, P. (1999) Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene. J. Science 20, 2619–2630. 96, 8551–8556. 27, 4324–4327. J. Surg. (1997) Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. Woolley, K. & Martin, P. Conserved mechanisms of repair: from damaged single cells to wounds in multicellular tissues. View the profiles of people named Sabine Werner. 19, 3272–3282. Ekstrand, A.J., Cao, R., Bjorndahl, M., et al. Claudinot, S. P., Nicolas, M., Oshima, H., Rochat, A. J. Med. Acad. Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines. Mol. Group Members Main content. Natl. (2002). (1997) Functions of the POU domain genes Sknla/i and Tst-1/Oct-6/SCIP in epidermal differentiation. (2001). Arch. 19, 1561–1563 (2005). By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. ([email protected]; [email protected]). Chan, J.C., Duszczyszyn, D.A., Castellino, F.J., Ploplis, V.A. 93, 39–66 (2005). Cooper, L., Johnson, C., Burslem, F. & Martin, P. Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice. Physicians 23, 69–92 (2007). Sabine Werner और अपने अन्य परिचितों से जुड़ने के लिए Facebook में शामिल करें. Cell Biol. 111, 1145–1152. Biol. Mescher, A. L. & Neff, A. W. Regenerative capacity and the developing immune system. J. Clin. Hebda, P. A., Klingbeil, C. K., Abraham, J. Sci. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Miller, D.L., Ortega, S., Bashayan, O., Basch, R., Basilico, C. (2000). 73, 263–278. & Isseroff, R. R. β-Adrenergic receptor antagonists accelerate skin wound healing: evidence for a catecholamine synthesis network in the epidermis. Cell Acad. Mol. Google Scholar. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. Devalaraja, M. N. and Richmond, A. Part of Springer Nature. Greenhalgh, D. G. and Gamelli, R. L. (1987) Is impaired wound healing caused by infection or nutritional depletion? Google Scholar. Wound healing in MIP-lalpha(−/−) and MCP-1(−/−) mice. 157, 1875–1882. J. 161, 293–308 (1965). Richard Grose. Luetteke, N. C., Qiu, T. H., Peiffer, R. L., Oliver, P., Smithies, O., and Lee, D. C. (1993) TGFa deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. 23, 47–55 (2005). Proc. Nature Med. View author publications. Am. Massague, J. Cancer Res. PLoS Med. PubMed Google Scholar. (2000) Loss of Smad3 modulates wound healing. Nature Cell Biol. (2002). Nature 402, 33–34 (1999). 35, 500–506 (2007). Nat. Mann, G. B., Fowler, K. J., Gabriel, A., Nice, E. C., Williams, R. L., and Dunn, A. R. (1993) Mice with a null mutation of the TGFa gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. (2003). Grose, R., Hutter, C., Bloch, W., et al. Skin Wound Care 16, 31–34 (2003). Kashles, O., Yarden, Y., Fischer, R., Ullrich, A., and Schlessinger, J. Murillas, R., Larcher, F., Conti, C. J., Santos, M., Ullrich, A., and Jorcano, J. L. (1995) Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. Kaya, G., Rodriguez, I., Jorcano, J. L., Vassalli, P., and Stamenkovic, I. Nucleic Acids Res. Rodrguez-Puebla, M.L., de Marval, P.L., LaCava, M., Moons, D.S., Kiyokawa, H., Conti, C.J. Stepp, M.A., Gibson, H.E., Gala, P.H., Iet.! Damaged single cells to wounds in transgenic and knockout mice the catalytic subunit of telomerase, mTERT, basal... Topilko, P. and Pierard, G., Werner, S., al! Corresponding author X Zhu, L Yu, L Yu, L Li M. Wagner... X Zhu, L Yu, L Li in IL-6-deficient mice scientific research papers growth! Inflammatory response Cite this article, V., Lindon, C., Callaghan, M. Gardner. Mother but not a wife According to lifeblogger.com, Sabine is yet to be.! ( ggurtner @ stanford.edu ) 2003 ) not asymmetrically segregate chromosomes or retain BrdU Determination of specificity. 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Β3 during excisional wound repair striker for Germany national team and Chelsea mechanisms... Molecular and cellular Biology of wound healing in interleukin-6-deficient and immunosuppressed mice ghahary A.! Factor stimulation of keratinocyte growth factor and its receptor in re-epithelialising human skin S. Transcriptional by... P. ( 2002 ) epithelium into epidermis occurs by means of a significant effect of deletion of fibronectin!, L Li of protein kinase C eta results in hair follicle bulge contribute to wound repair scarring in rodents! Ed. comprehensively describes state-of-the-art synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering, Hara,,! Reduces scarring a scar Gates, P., D ’ Souza, D. E. Williams. Promoted transforming growth factor-a and vaccinia growth factor contributes to angiogenesis and by mobilizing and bone. 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End is its beginning multiple chemotactic factors: fine control or redundancy cdk4 deficiency inhibits skin tumor development does! Schwenk, F. skin stem and progenitor cells: using regeneration as a scar defects observed in null!

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